Sun Exposure, Vitamin D Intake and Progression to Disability among Veterans with Progressive Multiple Sclerosis.
Background: Early life events have been suggested to influence multiple sclerosis (MS) susceptibility, and to potentially modulate its clinical course. We assessed vitamin D-related exposures from childhood to disease onset and their associations with MS progression. Methods: Among veterans in the Multiple Sclerosis Surveillance Registry, 219 reported having the progressive form and met the inclusion criteria. Participants reported their past sun exposure, vitamin D-related intake and age at disability milestones using the Patient-Determined Disease Steps (PDDS). The Cox proportional hazards model was used to examine the association between vitamin D-related exposures and time (years) to disability. Results: Low average sun exposure in the fall/winter before disease onset was associated with an increased risk of progressing to a PDDS score of 8 (hazard ratio, HR: 2.13, 95% confidence interval, CI: 1.20-3.78), whereas use of cod liver oil during childhood and adolescence was associated with a reduced risk (HR: 0.44, 95% CI: 0.20-0.96). Conclusions: These results suggest that exposure to vitamin D before MS onset might slow disease-related neurodegeneration and thus delay progression to disability among patients with the progressive subtype.
Really makes me wish I would have started taking a Vitamin D supplement years ago! Or spent more time in the sun! I wish I would have known to get my vitamin D levels checked earlier. Hopefully taking a vitamin D supplement now is helping to slow progression along with the injections and other vitamins/supplements. I realize that lack of vitamin D isn't the cause of MS, but it sure does seem to have some significant correlations. Always interesting to learn more about the disease.
Hey "CSA"
ReplyDeleteSorry to read about your diagnosis, my dad has parkinsons disease and can see him struggling every day, MS can be a painful thing to deal with but just realise that life is so precious, I wish you well with your illness, god bless you.
Mick.
Thank you for those kind words, Mick!
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