I intend this blog to be a mixture of my personal experiences with Multiple Sclerosis (MS) and news related to MS. Hopefully, I can shed an optimistic light on MS even though it is difficult to be an optimist living with MS.

Thursday, June 30, 2011

Estriol Study

From the NMSS website:

Summary: The National MS Society is funding a team of investigators at 15 medical centers to conduct a two-year, controlled clinical trial of an estrogen (estriol) added to standard therapy to treat MS. Investigators administer either oral estriol along with Copaxone® (glatiramer acetate, Teva Pharmaceutical Industries Ltd.) or Copaxone plus inactive placebo to 175 women with relapsing-remitting MS. If successful, this clinical trial could lay the groundwork for a larger, definitive trial that could lead to a new treatment option for women with MS, an option that would be a pill, not an injection. Importantly, the exclusion criteria for the study have recently changed, such that patients previously treated with an interferon or Copaxone will no longer be excluded. 
Fifteen Centers Recruiting Patients: The estriol trial is taking place at 15 medical centers across the U.S. Women between 18-50 who are diagnosed with relapsing remitting MS and are interested in participating in this clinical trial should contact the nearest site to discuss their eligibility:

UCLA; Dr. Barbara GiesserMike Montag310-794-4020
Washington University, St. Louis; Dr. Anne CrossDebbie Kemp314-362-3839
UMDNJ, New Brunswick; Dr. Suhayl Dhib-JalbutYaritza Rosario732-235-7099
OSU, Columbus; Dr. Michael RackeAndrea Schertzer614-366-3757
University of Chicago; Dr. Anthony RederMildred Valentine773-702-9812
University of Utah, Salt Lake; Dr. John RoseJulia Klein801-582-1565 x2014
U. of Texas Southwestern, Dallas; Dr. A. CourtneyGina Remington214-645-0560
Johns Hopkins U., Baltimore; Dr. John RatchfordE'tona Ford410-502-2489
University of Colorado, Aurora; Dr. John CorboyHaley Steinert303-724-4172
U. of New Mexico, Albuquerque; Dr. Corey FordLori Bachert505-272-8905
U. of Pennsylvania, Philadelphia; Dr. Dina JacobsVanessa Zimmerman215-349-5162
Dartmouth Med. Sch., Lebanon, NH; Dr. E. LallanaLaurie Rizzo603-653-9947
U. of Kansas, Kansas City; Dr. Sharon LynchKelly Dickerson913-588-0080
U. of Minnesota, Minneapolis; Dr. Gareth ParrySusan Rolandelli612-624-5978
Mayo Clinic Arizona, Scottsdale; Dr. D. WingerchukIrene Galasky480-301-6104

This study, costing more than $5 million, is being funded by the National MS Society – through the support of the Southern California Chapter and other chapters and private donors – and the National Institute of Neurological Disorders and Stroke. Adeona Pharmaceuticals is providing drug for the trial.
Rationale: Estriol levels rise to very high levels naturally during late pregnancy, a time when most women’s MS disease activity declines. This led some to suspect that estriol may be responsible for this easing of symptoms during pregnancy. Dr. Rhonda Voskuhl (University of California, Los Angeles) and others explored this lead in mice with MS-like disease, and later, with National MS Society support, Dr. Voskuhl conducted a small, early-phase trial of estriol in 12 women with MS. Results in mice showed that estriol treatment was indeed protective. Results in the pilot trial showed that estriol treatment decreased disease activity in women with relapsing-remitting MS.
According to Dr. Voskuhl, the trial principle investigator, in using estriol they “aim to simulate some of the disease protection offered by pregnancy. We are very enthusiastic about this new agent since it has decades of known safety and since it will be given as a pill, not a shot.” She further states, "Estriol treatment also has the potential to be more potent in halting disability in MS, since estrogens have been shown in animal models to be not only anti-inflammatory, but also to directly reduce brain injury."
Trial Details/Eligibility: The two-year study is a double-blind, placebo-controlled trial that will take place at 15 sites in the U.S. (listed above). Investigators will administer estriol in pill form to women between the ages of 18-50 who have a diagnosis of relapsing-remitting MS. The oral treatment will be given in combination with subcutaneously injected Copaxone, a standard treatment for MS, for 2 years. The team is evaluating effects of the treatment combination on relapse rates and several clinical and magnetic resonance imaging measures of disability progression.
Contact: For more information, contact the study sites listed above, or please see the study’s listing (NCT00451204) on ClinicalTrials.gov.
If you live in/near one of the above places and are interested in volunteering, be sure to contact the appropriate person ASAP!  This was placed on the NMSS website on 6/10/11 and it didn't say what the deadline is.  I think this is very exciting; I think Estriol has promise based on the previous research I have done regarding Estriol and MS (see Future Therapies Continued (BG-12 & Estriol)).


  1. I have been taking some kind of estrogen with copaxone for years. I have been taking estriol with copaxone for over a year. You can get the estriol at a compound pharmacy with a doctor's prescription. It is cheap ($36/month). I have been stable for years.

    I am too old to qualify for the study, but who cares?!

    1. I need some help. I'm paying $85 for 30 supply 8mg capsules of Esriol from a local compounding pharmacy. Would you be willing to give me the contact information for where you get yours from?
      Thank you =-)

    2. Good morning to all!Here in czech republic is 30tbs per 8 mg for approx 5USD.By my opinion it is very good idea to combine low dose naltrexon+estriol for long term treatment!
      peter haba,czech

  2. I was excluded from the study (talked to both LA and MN)becaus I had breast cancer..All I know is that I've been sayinf it for the past 6 years, "figure out the 'whys' of the pregnancy factor!" As many women with MS can attest, my symptoms DISAPPEARED while I was pregnant. At last, I believe someone has figured it out! God bless my neurologist for hooking me up w/ a compund pharmacy...been taking Estriol, along with my Gilenya, for the past 5 days...i have faith that after more than quarter of my 46 years, a glimpse of hope is right there... I'll keep reaching...and I'm gonna grab it & not let go. signed, 46 & ready...so is my 6 yr old!

  3. I'm so glad about this too...
    I used to take the pill before my MS onset, and when I left it the illness appeared. I didn't realise until a few months later, but then I started researching and I found about the pregnancy effects. I decided to start taking the pill again two years ago. My ginecologist and my neuro didn't agree with me, but the fact is I've had NOT A SINGLE RELAPSE since then.

    So now they're finally making trials with estrogens I feel there's a hope for many of us.

  4. Please let me know if any of you know of an estriol-based birth control pill.
    What dose of the estriol is effective against MS?
    I'm going to see if my Neurologist or OBGYN can prescribe for me, I know there is a compounding pharmacy near me. But I need to know the dose effective for MS, and if that dose is also considred effective as birth control (seeing as it mimics late pregnancy, I think it does).
    Thank you. : )


  5. I read in another on line article the dosage is 8mg a day. I even wrote this information in my notes so I could be knowledgable when I speak with my doctor next month. I typed Estriol into my computer and this article and the one about the 8 mg. both came up along with others.


  6. In an earlier article I read the dosage should be 8 mg daily. I found this information under estriol on the webb.

  7. I have been taking 8mg of Estriol ONLY to treat my RR MS and I have had no relapses of significance at all. If I push too hard, I have issues for a few days but that resolves.

    As soon as I read about Dr. Voskhul's small study, I began my own research. I have always gotten my estriol from "inhousepharmacy.com".